Developmental cell programs are co-opted in inflammatory skin disease

Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. In this atlas, gene expression in the two disease states studied—atopic dermatitis and psoriasis—varied from that in a healthy adult, suggesting that a fetal skin signature is expressed in adult inflamed skin. Furthermore, differences in immune cell composition between healthy fetal and adult skin and that of individuals suffering from disease were observed.

Contact
Muzlifah Haniffa
DOI
10.1126/science.aba6500
Release
22 January 2021
Lab
Haniffa Lab
Tissue
Fetal Skin, Skin
Assay
10x 3' v2, Smart-seq2
Disease
Atopic dermatitis, None, Psoriasis
Organism
Homo sapiens

scRNA-seq Datasets

Dataset
Tissue
Assay
Disease
Organism
Count
Skin
10x 3' v2
None
Homo sapiens
239045
Skin
10x 3' v2
None
Homo sapiens
200463
Skin
10x 3' v2
None, Atopic dermatitis, Psoriasis
Homo sapiens
539962
Fetal Skin
10x 3' v2
None
Homo sapiens
43432

Smart-seq2 Datasets

Dataset
Tissue
Assay
Disease
Organism
Count
Skin
Smart-seq2
None
Homo sapiens
1807

Reproducibility

Reproducibility is a major principle underpinning the scientific method. We make publicly available the raw data and analysis scripts associated with each collection.

Human Cell Atlas

Human Cell Atlas

Developmental

The Human Developmental Cell Atlas (HDCA) aims to generate a comprehensive profile of cell types and states present during development. This detailed study of development will be critical for understanding congenital and childhood disorders, as well as ageing.

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